![]() Jiang H, Xu Y, Iftimia N, Eggert J, Klove K, Baron L, Fajardo L: Three-dimensional optical tomographic imaging of breast in a human subject. Yodh AG, Chance B: Spectroscopy and imaging with diffusing light. Profio AE, Doiron DR: Transport of light in tissue in photodynamic therapy of cancer. These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer.Īmerican Cancer Society, Cancer Facts & Figures, 2003Īmerican Cancer Society, Cancer Prevention & Early Detection Facts & Figures, 2003 Images from this common experimental model show strong correlation with corresponding histopathology. OCT images of a well-established carcinogen-induced rat mammary tumor model were acquired. In this paper, an overview of the OCT technology is provided, followed by images demonstrating the feasibility of using OCT to image cellular features indicative of breast cancer. OCT performs optical ranging in tissue and is analogous to ultrasound except reflections of near-infrared light are detected rather than sound. Optical coherence tomography (OCT) is an emerging high-resolution biomedical imaging technology that for larger and undifferentiated cells can perform cellular-level imaging at the expense of imaging depth. While this technique permits non-invasive optical imaging of the whole breast, to date it is incapable of resolving features at the cellular level. Diffuse optical tomography is an optical imaging technique that has been pursued as an alternative to X-ray mammography. ![]() Optical imaging is capable of performing cellular and molecular imaging using the short wavelengths and spectroscopic properties of light. ![]() Diagnostic trends in medicine are being directed toward cellular and molecular processes, where treatment regimens are more amenable for cure.
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